
ID   AGA000066  standard; DNA; INV; 5195 BP.
XX
AC   BN000066;
XX
SV   BN000066.1
XX
DT   07-OCT-2002 (Rel. 73, Created)
DT   21-NOV-2002 (Rel. 73, Last updated, Version 11)
XX
DE   TPA: Anopheles gambiae achE1 gene for acetylcholinesterase, exons 1-6
XX
KW   acetylcholinesterase; achE1 gene; Third Party Annotation; TPA.
XX
OS   Anopheles gambiae (African malaria mosquito)
OC   Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera;
OC   Endopterygota; Diptera; Nematocera; Culicoidea; Anopheles.
XX
RN   [1]
RP   1-5195
RA   Fort P.P.;
RT   ;
RL   Submitted (30-NOV-2001) to the EMBL/GenBank/DDBJ databases.
RL   Fort P.P., CRBM-UPR1086, Cnrs, 1919 route de Mende, 34293 MONTPELLIER CEDEX
RL   5, FRANCE.
XX
RN   [3]
RA   Weill M., Fort P., Berthomi eu A., Dubois M.P., Pasteur N., Raymond M.;
RT   "A novel acetylcholinesterase gene in mosquitoes codes for the insecticide
RT   target and is non-homologous to the ace gene in Drosophila";
RL   Proc. R. Soc. Lond., B, Biol. Sci. 269:2007-2016(2002).
XX
CC   see also AJ488492 for achE-1 from Kisumu strain
CC   Third Party Annotation Database: This TPA record uses Anopheles gambiae
CC   trace archive data (http://trace.ensembl.org)
XX
AH   TPA_SPAN        PRIMARY_IDENTIFIER   PRIMARY_SPAN   COMP
AS   1-685           TI55475028           11-685             
AS   1-747           TI47553499           11-747             
AS   1-800           TI55407518           11-800             
AS   188-895         TI57630934           11-707             
AS   223-845         TI57283198           11-622             
AS   251-895         TI47098900           11-644             
AS   272-999         TI56725015           11-727             
AS   387-1193        TI57310066           11-806             
AS   431-1195        TI56845856           11-764             
AS   522-1220        TI55215818           11-698             
AS   546-1208        TI57401582           11-661             
AS   566-1208        TI56169014           11-642             
AS   584-1306        TI59761948           11-722             
AS   738-1306        TI55852606           11-568             
AS   827-1634        TI57602219           11-807             
AS   1064-1769       TI44966390           11-705             
AS   1065-1822       TI60742945           11-757             
AS   1129-1954       TI56042882           11-825             
AS   1223-1979       TI60461178           11-756             
AS   1226-1868       TI56472916           11-642             
AS   1296-1989       TI44952509           11-693             
AS   1364-2170       TI56006358           11-806             
AS   1561-2341       TI58704241           11-780             
AS   1582-2385       TI44875600           11-803             
AS   1740-2415       TI55894404           11-675             
AS   1794-2585       TI56056818           11-791             
AS   1834-2644       TI47256770           11-809             
AS   1848-2729       TI56446066           11-879             
AS   1849-2515       TI44984669           11-665             
AS   2216-3002       TI57417259           11-786             
AS   2224-3029       TI56867244           11-805             
AS   2226-3057       TI59803037           11-831             
AS   2299-3083       TI60503347           11-784             
AS   2614-3351       TI44891398           11-736             
AS   2654-3419       TI55336738           11-765             
AS   2663-3304       TI60709914           11-641             
AS   2672-3417       TI56453591           11-745             
AS   2691-3260       TI55690247           11-569             
AS   2697-3494       TI55745954           11-797             
AS   2885-3706       TI58733608           11-821             
AS   2896-3700       TI58130218           11-803             
AS   2946-3741       TI56432498           11-795             
AS   2992-3702       TI47561255           11-710             
AS   2992-3702       TI55208429           11-710             
AS   3029-3807       TI47256418           11-778             
AS   3030-3831       TI47233061           11-801             
AS   3123-3892       TI55870944           11-769             
AS   3255-4043       TI47465031           11-787             
AS   3325-4045       TI55382589           11-720             
AS   3535-4255       TI46993841           11-720             
AS   3574-4244       TI56607077           11-670             
AS   3596-4394       TI56526265           11-798             
AS   3704-4484       TI56050293           11-780             
AS   3724-4560       TI59807029           11-836             
AS   3745-4549       TI55159438           11-804             
AS   3753-4596       TI56586965           11-842             
AS   3800-4577       TI56592754           11-777             
AS   3833-4635       TI47243257           11-801             
AS   3837-4272       TI59628661           11-435             
AS   3899-4728       TI56895999           11-829             
AS   3938-4704       TI59830483           11-766             
AS   3942-4704       TI55700050           11-762             
AS   4116-4912       TI56961976           11-796             
AS   4137-4761       TI46929238           11-623             
AS   4148-4961       TI59909853           11-813             
AS   4285-5046       TI47085450           11-759             
AS   4315-5069       TI58096045           11-754             
AS   4387-5177       TI58084392           11-790             
AS   4455-5175       TI55094688           11-720             
AS   4455-5195       TI55297322           11-740             
AS   4491-5195       TI56990277           11-704             
XX
FH   Key             Location/Qualifiers
FH
FT   source          1..5195
FT                   /db_xref="taxon:7165"
FT                   /organism="Anopheles gambiae"
FT   CDS             join(<1780..1914,2001..2538,2618..2815,2902..3609,
FT                   3676..3848,3956..4077)
FT                   /codon_start=3
FT                   /gene="achE1"
FT                   /product="acetylcholinesterase"
FT                   /EC_number="3.1.1.7"
FT                   /function="hydrolyzes acetylcholine at cholinergic
FT                   synapses"
FT                   /protein_id="CAD29865.2"
FT                   /translation="AFFTPYIGHGESVRIIDAELGTLEHVHSGATPRRRGLTRRESNSD
FT                   ANDNDPLVVNTDKGRIRGITVDAPSGKKVDVWLGIPYAQPPVGPLRFRHPRPAEKWTGV
FT                   LNTTTPPNSCVQIVDTVFGDFPGATMWNPNTPLSEDCLYINVVAPRPRPKNAAVMLWIF
FT                   GGGFYSGTATLDVYDHRALASEENVIVVSLQYRVASLGFLFLGTPEAPGNAGLFDQNLA
FT                   LRWVRDNIHRFGGDPSRVTLFGESAGAVSVSLHLLSALSRDLFQRAILQSGSPTAPWAL
FT                   VSREEATLRALRLAEAVGCPHEPSKLSDAVECLRGKDPHVLVNNEWGTLGICEFPFVPV
FT                   VDGAFLDETPQRSLASGRFKKTEILTGSNTEEGYYFIIYYLTELLRKEEGVTVTREEFL
FT                   QAVRELNPYVNGAARQAIVFEYTDWTEPDNPNSNRDALDKMVGDYHFTCNVNEFAQRYA
FT                   EEGNNVYMYLYTHRSKGNPWPRWTGVMHGDEINYVFGEPLNPTLGYTEDEKDFSRKIMR
FT                   YWSNFAKTGNPNPNTASSEFPEWPKHTAHGRHYLELGLNTSFVGRGPRLRQCAFWKKYL
FT                   PQLVAATSNLPGPAPPSEPCESSAFFYRPDLIVLLVSLLTATVRFIQ"
FT   mRNA            join(<1780..1914,2001..2538,2618..2815,2902..3609,
FT                   3676..3848,3956..>4596)
FT                   /gene="achE1"
FT   exon            <1780..1914
FT                   /number=1
FT                   /gene="achE1"
FT   intron          1915..2000
FT                   /number=1
FT                   /gene="achE1"
FT   exon            2001..2538
FT                   /number=2
FT                   /gene="achE1"
FT   intron          2539..2617
FT                   /number=2
FT                   /gene="achE1"
FT   exon            2618..2815
FT                   /number=3
FT                   /gene="achE1"
FT   intron          2816..2901
FT                   /number=3
FT                   /gene="achE1"
FT   exon            2902..3609
FT                   /number=4
FT                   /gene="achE1"
FT   intron          3610..3675
FT                   /number=4
FT                   /gene="achE1"
FT   exon            3676..3848
FT                   /number=5
FT                   /gene="achE1"
FT   intron          3849..3955
FT                   /number=5
FT                   /gene="achE1"
FT   exon            3956..>4596
FT                   /number=6
FT                   /gene="achE1"
FT   polyA_signal    4628..4633
FT                   /gene="achE1"
XX
SQ   Sequence 5195 BP; 1326 A; 1468 C; 1183 G; 1218 T; 0 other;
     gaggtggatt ggtacggatt ggtcatttcc gttcttcttc atgtgcgttt cttactctcc        60
     tgccttctca aacgaacttc agaacgaaaa aaaacacgcg acggagagta agaagctgta       120
     cagacactct agtcctcaca cacacaactt gcttactttg tccgtccgtt tgattccgct       180
     ctttctatgt gtgactttct ggcacccttt acttcgtcac tattcatttc atttccaata       240
     aacttttaat gtgtctttct tttttattct aaatatctat agtaaatgtt ctgtagcaag       300
     tatcttgtag tagaattgta tagaagtaga tttttgtatg agtttgcatc atcccttccc       360
     aatggggttg actccgtttc aaccaacgcc aaaagctatc ggcataaagt atggttcctt       420
     gcaaaggctt ttatgaaaca cgaatgtgtt gaaagctttt gcaaatggaa atgttaaagc       480
     ctttaagttc caatcgcttt ttgtatccat ttagtttgca tgaacaacag gaaatcaaaa       540
     tattggtaac gacaatcgct ggcgggcgtt cctttcttgt ctaatcaaat catctacgat       600
     tgtaattaca aacttccaag tttgcgtatg acaatgttaa atgtctaaga cgctcaaatg       660
     caaccaatag agtataatta ctaaggcggg cagtagaaac caaaatatct taaataatgt       720
     caagcaaaac aaaaagaaca attccgttca ctgctcaaag aaagccctaa ctaactacct       780
     aaccttttca tcgatgaccc tgtactgaca tggtaagata ttctttatcc tttaactctt       840
     ctgcacccta cgcactcaat gcaacacacg cactactatt actgctacta ctctcgcact       900
     cacgagcacc tacttgcact caagccggca ctcaatgtac tagcgaaaca cgtcgcatct       960
     aagcactcac aaggaagcac acatttgcaa atagcaccta ccggaacagc tttgaatgtg      1020
     ccagcacagc attgaacagg ttcgcgcctt tactcctgtg ctctgttttc tcgatcggaa      1080
     tgttcgaaag ttgaaaagcg cattttttca tctctctttt tctattcttc ttcgtatttt      1140
     tatccctctc tcgtcgtgtt ttttctaaac attaccatac ttcttccgct acgaactcgc      1200
     caagaaccag aacgcagcgt gcgtgcggtg cttgcggtgt gtgtgtgtgt gtgtgtattc      1260
     cacggctgcg agaagcaaga tcggagaaca ggcatcattc ccctttcaca gacaattgca      1320
     cttttgtact agaacagaaa acgagacagc ataatttcca acagcctcat tcactcatac      1380
     caggctcaca ccgactttta accgaaacat gtactacaga aacaaaaaca aacaatatgg      1440
     agagtgctcg cgctgatact aagttaatat gaagagatta ctggcgaggt catcgatccc      1500
     atcccgacat catcgctcca ggctccagac ctaccaagtc gcctaccatt acctacccac      1560
     caccgaccac tactcacaca gcattatcac ttccgccgcc gtcgccgccg ccgccgacgc      1620
     cgccgacgcc accaccttca caccgccctg ccaaaatgaa tgcgcattgt tgcgatagat      1680
     tgaatttcct tggttgttgt tgttgttggt tttcttttga catgtttgtg tgttgttttt      1740
     tctttctctc tctctctttc tgtggttcca acatttcaga cgcatttttt acaccatata      1800
     taggtcacgg tgagtccgta cgaattatag atgccgagtt gggcacgctc gagcatgtcc      1860
     acagtggagc aacgccgcgg cgacgcggcc tgacgaggcg cgagtcaaac tcgggtaagt      1920
     acgcgattgg aagtgggggg acgtttaccc taccgtgtac tactacaacg cactttaccc      1980
     ccacgcacac gcaccggcag acgcgaacga caacgatccg ctggtggtca acacggataa      2040
     ggggcgcatc cgcggcatta cggtcgatgc gcccagcggc aagaaggtgg acgtgtggct      2100
     cggcattccc tacgcccagc cgccggtcgg gccgctacgg ttccgtcatc cgcggccggc      2160
     cgaaaagtgg accggcgtgc tgaacacgac cacaccgccc aacagctgcg tgcagatcgt      2220
     ggacaccgtg ttcggcgact tcccgggcgc gaccatgtgg aacccgaaca cgcccctgtc      2280
     cgaggactgt ctgtacatta acgtggtggc accgcgaccc cggcccaaga atgcggccgt      2340
     catgctgtgg atcttcggcg gcggcttcta ctccggcacc gccaccctgg acgtgtacga      2400
     ccaccgggcg cttgcgtcgg aggagaacgt gatcgtggtg tcgctgcagt accgcgtggc      2460
     cagtctgggc ttcctgtttc tcggcacccc ggaagcgccg ggcaatgcgg gactgttcga      2520
     tcagaacctt gcgctacggt aggtgtcttt gcatgtgtga atgagggtat agtattctaa      2580
     cgaggtgctc ttcttcccat cacttcttgg gagtcagctg ggtgcgggac aacattcacc      2640
     ggttcggtgg cgatccgtcg cgtgtgacac tgttcggcga gagtgccggt gccgtctcgg      2700
     tgtcgctgca tctgctgtcc gccctttccc gcgatctgtt ccagcgggcc atcctgcaga      2760
     gcggctcgcc gacggcaccg tgggcattgg tatcgcgcga ggaagccaca ctaaggtacg      2820
     tgccagctgc tgctttcccc aaaccaccaa cccgcaacag ctcacacaac cctcttttcc      2880
     gtcgctcttt tctcgctcca gagcactgcg gttggccgag gcggtcggct gcccgcacga      2940
     accgagcaag ctgagcgatg cggtcgagtg cctgcgcggc aaggacccgc acgtgctggt      3000
     caacaacgag tggggcacgc tcggcatttg cgagttcccg ttcgtgccgg tggtcgacgg      3060
     tgcgttcctg gacgagacgc cgcagcgttc gctcgccagc gggcgcttca agaagacgga      3120
     gatcctcacc ggcagcaaca cggaggaggg ctactacttc atcatctact acctgaccga      3180
     gctgctgcgc aaggaggagg gcgtgaccgt gacgcgcgag gagttcctgc aggcggtgcg      3240
     cgagctcaac ccgtacgtga acggggcggc ccggcaggcg atcgtgttcg agtacaccga      3300
     ctggaccgag ccggacaacc cgaacagcaa ccgggacgcg ctggacaaga tggtgggcga      3360
     ctatcacttc acctgcaacg tgaacgagtt cgcgcagcgg tacgccgagg agggcaacaa      3420
     cgtctacatg tatctgtaca cgcaccgcag caaaggcaac ccgtggccgc gctggacggg      3480
     cgtgatgcac ggcgacgaga tcaactacgt gttcggcgaa ccgctcaacc ccaccctcgg      3540
     ctacaccgag gacgagaaag actttagccg gaagatcatg cgatactggt ccaactttgc      3600
     caaaaccggg taagtgtgtg tgtcaaacag cagagtgtcg atcgctctaa caccagcgtc      3660
     ttctctcttc tacagcaatc caaatcccaa cacggccagc agcgaattcc ccgagtggcc      3720
     caagcacacc gcccacggac ggcactatct ggagctgggc ctcaacacgt ccttcgtcgg      3780
     tcggggccca cggttgaggc agtgtgcctt ctggaagaag taccttcccc agctagttgc      3840
     agctacctgt aagtctcgtg cagcacttga aaccccctcc cacatcccca tcagggtcca      3900
     ggttgcaata ataaatttca ctttctctct ctcacgtctc ttttccccaa aacagcgaac      3960
     ctaccagggc cagcaccgcc tagtgaaccg tgcgaaagca gcgcattttt ttaccgacct      4020
     gatctgatcg tgctgctggt gtcgctgctt acggcgaccg tcagattcat acaataatta      4080
     ctaccccatc catggcctag ttcgtttaag ctttaagata gtgaggaaca aatttttccc      4140
     aaacaatttt ccccccttta gagcagaacc gagggagaga taggactaca tagcgaaaag      4200
     ggaaaacaag tggtggcgga cgaggagaga agaagcaaat cgaataatcg aagcaacaac      4260
     aacaacaaca aaaaaactgc aaccgggttc actaaaccca gggggcagct cagtagcaaa      4320
     ctactactta aataactact ttcttatggc aaattatggc aagagcagtc gtgatgggtt      4380
     cgatcagtat ccatctgacc ggagcagctg aaccgtttca tgggcagttg ctgcaataca      4440
     ccacgacccg tacacacagt aacacacttt ttatagcttt acactaacaa ccactctccc      4500
     cacgctcctc ttccccttcc cctccacaca gacagcagcg ccgtttgtag caggatctac      4560
     taccgtgcgg tttggtatgg cggccaacaa cactaaacac cacacatcta ctaaaacaca      4620
     ccggaacaat aaacaaatgt taaacttact atatgaatat acatctagac gcatatatac      4680
     gcatgaacta ctacttccct cgtgttctga caaaacacat taccttgtcc cccctccccc      4740
     tccggtttgc ttaccaccac tgcaccacca gtatgaattt gttccataat aacgcttcgt      4800
     aactcgttac caggagcaca actgggtcgt tggcggagtg ctgcgcgttt cgtgctgaag      4860
     atgtaaacta gcaccgcgca cactttcgac acgcaaccac agctacacat cacgaaagca      4920
     acatcctggc cctatccgtt ttctcattct taaaacttct ttccttagac caaaaccaac      4980
     gcaaactagc aaaaggtact tgagtaaccg gtccagtaca cactgtgcta caattgagcg      5040
     tagggaggag gtataatttc tgcaaaatgt ataaaacaaa actaaaacaa actaattact      5100
     tgcaatccat tctaaagcac gaaaactcct caaaataaaa acgggaagta aacaaaaaaa      5160
     tcagaacgaa caaatttacc taaaaaaaag taaac                                 5195
//

