LOCUS       NC_002058               7440 bp ss-RNA     linear   VRL 08-DEC-2008
DEFINITION  Poliovirus, complete genome.
ACCESSION   NC_002058
VERSION     NC_002058.3  GI:12408699
DBLINK      BioProject: PRJNA15288
DBLINK      Project:100,200,300
DBLINK      NC_002058.3
KEYWORDS    coat protein; complementary DNA; genome; polyprotein.
SOURCE      Human enterovirus C
  ORGANISM  Human enterovirus C
            Viruses; ssRNA positive-strand viruses, no DNA stage;
            Picornavirales; Picornaviridae; Enterovirus.
REFERENCE   1  (sites)
  AUTHORS   Dorner,A.J., Dorner,L.F., Larsen,G.R., Wimmer,E. and Anderson,C.W.
  TITLE     Identification of the initiation site of poliovirus polyprotein
            synthesis
  JOURNAL   J. Virol. 42 (3), 1017-1028 (1982)
   PUBMED   6284987
REFERENCE   2  (sites)
  AUTHORS   Emini,E.A., Elzinga,M. and Wimmer,E.
  TITLE     Carboxy-terminal analysis of poliovirus proteins: termination of
            poliovirus RNA translation and location of unique poliovirus
            polyprotein cleavage sites
  JOURNAL   J. Virol. 42 (1), 194-199 (1982)
   PUBMED   6283138
REFERENCE   3  (bases 1 to 7440)
  AUTHORS   Racaniello,V.R. and Baltimore,D.
  TITLE     Molecular cloning of poliovirus cDNA and determination of the
            complete nucleotide sequence of the viral genome
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 78 (8), 4887-4891 (1981)
   PUBMED   6272282
REFERENCE   4  (bases 1 to 7440)
  AUTHORS   Kitamura,N., Semler,B.L., Rothberg,P.G., Larsen,G.R., Adler,C.J.,
            Dorner,A.J., Emini,E.A., Hanecak,R., Lee,J.J., van der Werf,S.,
            Anderson,C.W. and Wimmer,E.
  TITLE     Primary structure, gene organization and polypeptide expression of
            poliovirus RNA
  JOURNAL   Nature 291 (5816), 547-553 (1981)
   PUBMED   6264310
REFERENCE   5  (bases 5360 to 5527)
  AUTHORS   Kitamura,N., Adler,C.J., Rothberg,P.G., Martinko,J., Nathenson,S.G.
            and Wimmer,E.
  TITLE     The genome-linked protein of picornaviruses. VII. Genetic mapping
            of poliovirus VPg by protein and RNA sequence studies
  JOURNAL   Cell 21 (1), 295-302 (1980)
   PUBMED   6250717
REFERENCE   6  (bases 6383 to 7440)
  AUTHORS   Kitamura,N. and Wimmer,E.
  TITLE     Sequence of 1060 3'-terminal nucleotides of poliovirus RNA as
            determined by a modification of the dideoxynucleotide method
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 77 (6), 3196-3200 (1980)
   PUBMED   6158042
REFERENCE   7  (bases 1 to 7440)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2000) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from V01149.
            On Jan 24, 2001 this sequence version replaced gi:12331600.
            See also entries V01148 (POLIO1A, for another version of this
            genome) and V01150 (POLIOS1, for the genome of the Sabin 1 strain).
            See the entry V01148 (POLIO1A) for the sequence reported in [3].
            Mature peptides were added to the annotation by NCBI RefSeq Genomes
            staff.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..7440
                     /organism="Human enterovirus C"
                     /mol_type="genomic RNA"
                     /strain="Human poliovirus 1 Mahoney"
                     /db_xref="taxon:138950"
     conflict        284..288
                     /note="CGCUC is GUU in [3]"
                     /citation=[4]
     conflict        352
                     /note="G is U in [3]"
                     /citation=[4]
     conflict        387
                     /note="GC is C in [3]"
                     /citation=[4]
     conflict        488
                     /note="G is GU in [3]"
                     /citation=[4]
     gene            743..7372
                     /locus_tag="PVgp1"
                     /db_xref="GeneID:919920"
     CDS             743..7372
                     /locus_tag="PVgp1"
                     /codon_start=1
                     /product="polyprotein"
                     /protein_id="NP_041277.1"
                     /db_xref="GI:9627037"
                     /db_xref="GOA:P03300"
                     /db_xref="UniProtKB/Swiss-Prot:P03300"
                     /db_xref="GeneID:919920"
                     /translation="MGAQVSSQKVGAHENSNRAYGGSTINYTTINYYRDSASNAASKQ
                     DFSQDPSKFTEPIKDVLIKTAPMLNSPNIEACGYSDRVLQLTLGNSTITTQEAANSVV
                     AYGRWPEYLRDSEANPVDQPTEPDVAACRFYTLDTVSWTKESRGWWWKLPDALRDMGL
                     FGQNMYYHYLGRSGYTVHVQCNASKFHQGALGVFAVPEMCLAGDSNTTTMHTSYQNAN
                     PGEKGGTFTGTFTPDNNQTSPARRFCPVDYLLGNGTLLGNAFVFPHQIINLRTNNCAT
                     LVLPYVNSLSIDSMVKHNNWGIAILPLAPLNFASESSPEIPITLTIAPMCCEFNGLRN
                     ITLPRLQGLPVMNTPGSNQYLTADNFQSPCALPEFDVTPPIDIPGEVKNMMELAEIDT
                     MIPFDLSATKKNTMEMYRVRLSDKPHTDDPILCLSLSPASDPRLSHTMLGEILNYYTH
                     WAGSLKFTFLFCGFMMATGKLLVSYAPPGADPPKKRKEAMLGTHVIWDIGLQSSCTMV
                     VPWISNTTYRQTIDDSFTEGGYISVFYQTRIVVPLSTPREMDILGFVSACNDFSVRLL
                     RDTTHIEQKALAQGLGQMLESMIDNTVRETVGAATSRDALPNTEASGPTHSKEIPALT
                     AVETGATNPLVPSDTVQTRHVVQHRSRSESSIESFFARGACVTIMTVDNPASTTNKDK
                     LFAVWKITYKDTVQLRRKLEFFTYSRFDMELTFVVTANFTETNNGHALNQVYQIMYVP
                     PGAPVPEKWDDYTWQTSSNPSIFYTYGTAPARISVPYVGISNAYSHFYDGFSKVPLKD
                     QSAALGDSLYGAASLNDFGILAVRVVNDHNPTKVTSKIRVYLKPKHIRVWCPRPPRAV
                     AYYGPGVDYKDGTLTPLSTKDLTTYGFGHQNKAVYTAGYKICNYHLATQDDLQNAVNV
                     MWSRDLLVTESRAQGTDSIARCNCNAGVYYCESRRKYYPVSFVGPTFQYMEANNYYPA
                     RYQSHMLIGHGFASPGDCGGILRCHHGVIGIITAGGEGLVAFSDIRDLYAYEEEAMEQ
                     GITNYIESLGAAFGSGFTQQISDKITELTNMVTSTITEKLLKNLIKIISSLVIITRNY
                     EDTTTVLATLALLGCDASPWQWLRKKACDVLEIPYVIKQGDSWLKKFTEACNAAKGLE
                     WVSNKISKFIDWLKEKIIPQARDKLEFVTKLRQLEMLENQISTIHQSCPSQEHQEILF
                     NNVRWLSIQSKRFAPLYAVEAKRIQKLEHTINNYIQFKSKHRIEPVCLLVHGSPGTGK
                     SVATNLIARAIAERENTSTYSLPPDPSHFDGYKQQGVVIMDDLNQNPDGADMKLFCQM
                     VSTVEFIPPMASLEEKGILFTSNYVLASTNSSRISPPTVAHSDALARRFAFDMDIQVM
                     NEYSRDGKLNMAMATEMCKNCHQPANFKRCCPLVCGKAIQLMDKSSRVRYSIDQITTM
                     IINERNRRSNIGNCMEALFQGPLQYKDLKIDIKTSPPPECINDLLQAVDSQEVRDYCE
                     KKGWIVNITSQVQTERNINRAMTILQAVTTFAAVAGVVYVMYKLFAGHQGAYTGLPNK
                     KPNVPTIRTAKVQGPGFDYAVAMAKRNIVTATTSKGEFTMLGVHDNVAILPTHASPGE
                     SIVIDGKEVEILDAKALEDQAGTNLEITIITLKRNEKFRDIRPHIPTQITETNDGVLI
                     VNTSKYPNMYVPVGAVTEQGYLNLGGRQTARTLMYNFPTRAGQCGGVITCTGKVIGMH
                     VGGNGSHGFAAALKRSYFTQSQGEIQWMRPSKEVGYPIINAPSKTKLEPSAFHYVFEG
                     VKEPAVLTKNDPRLKTDFEEAIFSKYVGNKITEVDEYMKEAVDHYAGQLMSLDINTEQ
                     MCLEDAMYGTDGLEALDLSTSAGYPYVAMGKKKRDILNKQTRDTKEMQKLLDTYGINL
                     PLVTYVKDELRSKTKVEQGKSRLIEASSLNDSVAMRMAFGNLYAAFHKNPGVITGSAV
                     GCDPDLFWSKIPVLMEEKLFAFDYTGYDASLSPAWFEALKMVLEKIGFGDRVDYIDYL
                     NHSHHLYKNKTYCVKGGMPSGCSGTSIFNSMINNLIIRTLLLKTYKGIDLDHLKMIAY
                     GDDVIASYPHEVDASLLAQSGKDYGLTMTPADKSATFETVTWENVTFLKRFFRADEKY
                     PFLIHPVMPMKEIHESIRWTKDPRNTQDHVRSLCLLAWHNGEEEYNKFLAKIRSVPIG
                     RALLLPEYSTLYRRWLDSF"
     mat_peptide     746..949
                     /locus_tag="PVgp1"
                     /product="coat protein VP4"
                     /protein_id="NP_740468.1"
                     /db_xref="GI:25121840"
     mat_peptide     950..1765
                     /locus_tag="PVgp1"
                     /product="coat protein VP2"
                     /protein_id="NP_740469.1"
                     /db_xref="GI:25121841"
     mat_peptide     1766..2479
                     /locus_tag="PVgp1"
                     /product="coat protein VP3"
                     /protein_id="NP_740470.1"
                     /db_xref="GI:25121842"
     mat_peptide     2480..3385
                     /locus_tag="PVgp1"
                     /product="coat protein VP1"
                     /protein_id="NP_740471.1"
                     /db_xref="GI:25121843"
     mat_peptide     3386..3832
                     /locus_tag="PVgp1"
                     /product="Picornain 2A"
                     /note="Small chymotrypsin-like cysteine proteinase"
                     /protein_id="NP_740477.1"
                     /db_xref="GI:25121849"
     mat_peptide     3833..4123
                     /locus_tag="PVgp1"
                     /product="protein 2B"
                     /protein_id="NP_740472.1"
                     /db_xref="GI:25121844"
     mat_peptide     4124..5110
                     /locus_tag="PVgp1"
                     /product="protein 2C (NTPase)"
                     /note="Involved in initiation and elongation of RNA
                     synthesis, RNA encapsidation, virus uncoating and
                     guanidine resistance (Asn179-Gly mutation). Putative
                     helicase III."
                     /protein_id="NP_740473.1"
                     /db_xref="GI:25121845"
     mat_peptide     5111..5371
                     /locus_tag="PVgp1"
                     /product="protein 3A"
                     /protein_id="NP_740474.1"
                     /db_xref="GI:25121846"
     mat_peptide     5372..5437
                     /locus_tag="PVgp1"
                     /product="genome linked protein VPg"
                     /protein_id="NP_740475.1"
                     /db_xref="GI:25121847"
     mat_peptide     5438..5986
                     /locus_tag="PVgp1"
                     /product="Picornain 3C"
                     /note="Chymotrypsin-like cystein proteinase 3C"
                     /protein_id="NP_740476.2"
                     /db_xref="GI:62871476"
     mat_peptide     5987..7369
                     /locus_tag="PVgp1"
                     /product="RNA-directed RNA-polymerase 3D"
                     /protein_id="NP_740478.2"
                     /db_xref="GI:62871477"
     conflict        1467..1468
                     /locus_tag="PVgp1"
                     /note="GG is G in [3]"
                     /citation=[4]
     conflict        1529..1530
                     /locus_tag="PVgp1"
                     /note="CC is C in [3]"
                     /citation=[4]
     conflict        1534..1535
                     /locus_tag="PVgp1"
                     /note="CC is C in [3]"
                     /citation=[4]
     conflict        1547
                     /locus_tag="PVgp1"
                     /note="C is U in [3]"
                     /citation=[4]
     conflict        1579
                     /locus_tag="PVgp1"
                     /note="C is A in [3]"
                     /citation=[4]
     conflict        1601
                     /locus_tag="PVgp1"
                     /note="A is C in [3]"
                     /citation=[4]
     conflict        1668
                     /locus_tag="PVgp1"
                     /note="C is U in [3]"
                     /citation=[4]
     conflict        2001
                     /locus_tag="PVgp1"
                     /note="A is C in [3]"
                     /citation=[4]
     conflict        2004..2006
                     /locus_tag="PVgp1"
                     /note="AUC is CCU in [3]"
                     /citation=[4]
     conflict        2035
                     /locus_tag="PVgp1"
                     /note="U is C in [3]"
                     /citation=[4]
     conflict        2133
                     /locus_tag="PVgp1"
                     /note="U is C in [3]"
                     /citation=[4]
     conflict        2286
                     /locus_tag="PVgp1"
                     /note="C is G in [3]"
                     /citation=[4]
     conflict        2983
                     /locus_tag="PVgp1"
                     /note="G is A in [3]"
                     /citation=[4]
     conflict        3043
                     /locus_tag="PVgp1"
                     /note="A is G in [3]"
                     /citation=[4]
     conflict        3303..3304
                     /locus_tag="PVgp1"
                     /note="GG is G in [3]"
                     /citation=[4]
     conflict        3308
                     /locus_tag="PVgp1"
                     /note="G is GC in [3]"
                     /citation=[4]
     conflict        3657
                     /locus_tag="PVgp1"
                     /note="C is U in [3]"
                     /citation=[4]
     conflict        3696
                     /locus_tag="PVgp1"
                     /note="C is A in [3]"
                     /citation=[4]
     conflict        3766
                     /locus_tag="PVgp1"
                     /note="C is A in [3]"
                     /citation=[4]
     conflict        4158
                     /locus_tag="PVgp1"
                     /note="C is CC in [3]"
                     /citation=[4]
     conflict        4163..4164
                     /locus_tag="PVgp1"
                     /note="GC is G in [3]"
                     /citation=[4]
     conflict        4174
                     /locus_tag="PVgp1"
                     /note="A is C in [3]"
                     /citation=[4]
     conflict        5113
                     /locus_tag="PVgp1"
                     /note="A is C in [3]"
                     /citation=[4]
     conflict        5598
                     /locus_tag="PVgp1"
                     /note="U is C in [3]"
                     /citation=[4]
     conflict        5619..5623
                     /locus_tag="PVgp1"
                     /note="CGCUC is UGUUU in [3]"
                     /citation=[4]
     conflict        5645
                     /locus_tag="PVgp1"
                     /note="C is U in [3]"
                     /citation=[4]
     conflict        5786
                     /locus_tag="PVgp1"
                     /note="G is C in [3]"
                     /citation=[4]
     conflict        5903..5905
                     /locus_tag="PVgp1"
                     /note="AAA is AA in [3]"
                     /citation=[4]
     conflict        5927..5931
                     /locus_tag="PVgp1"
                     /note="GGGAA is GGA in [3]"
                     /citation=[4]
     conflict        5970..5971
                     /locus_tag="PVgp1"
                     /note="AC is UA in [3]"
                     /citation=[4]
     conflict        5997
                     /locus_tag="PVgp1"
                     /note="A is C in [3]"
                     /citation=[4]
     conflict        6019
                     /locus_tag="PVgp1"
                     /note="A is C in [3]"
                     /citation=[4]
     conflict        6021
                     /locus_tag="PVgp1"
                     /note="U is C in [3]"
                     /citation=[4]
     conflict        6261
                     /locus_tag="PVgp1"
                     /note="C is U in [3]"
                     /citation=[4]
     conflict        6845..6847
                     /locus_tag="PVgp1"
                     /note="CCA is CA in [2]"
                     /citation=[5]
     conflict        6978..6979
                     /locus_tag="PVgp1"
                     /note="UU is UUU in [2]"
                     /citation=[5]
     conflict        7258
                     /locus_tag="PVgp1"
                     /note="U is UU in [2]"
                     /citation=[5]
     conflict        7410
                     /note="U is C in [3] and [2]"
                     /citation=[4]
                     /citation=[5]
     conflict        7440
                     /note="G is GG in [3] and [2]"
                     /citation=[4]
                     /citation=[5]
ORIGIN      
        1 ttaaaacagc tctggggttg tacccacccc agaggcccac gtggcggcta gtactccggt
       61 attgcggtac ccttgtacgc ctgttttata ctcccttccc gtaacttaga cgcacaaaac
      121 caagttcaat agaagggggt acaaaccagt accaccacga acaagcactt ctgtttcccc
      181 ggtgatgtcg tatagactgc ttgcgtggtt gaaagcgacg gatccgttat ccgcttatgt
      241 acttcgagaa gcccagtacc acctcggaat cttcgatgcg ttgcgctcag cactcaaccc
      301 cagagtgtag cttaggctga tgagtctgga catccctcac cggtgacggt ggtccaggct
      361 gcgttggcgg cctacctatg gctaacgcca tgggacgcta gttgtgaaca aggtgtgaag
      421 agcctattga gctacataag aatcctccgg cccctgaatg cggctaatcc caacctcgga
      481 gcaggtggtc acaaaccagt gattggcctg tcgtaacgcg caagtccgtg gcggaaccga
      541 ctactttggg tgtccgtgtt tccttttatt ttattgtggc tgcttatggt gacaatcaca
      601 gattgttatc ataaagcgaa ttggattggc catccggtga aagtgagact cattatctat
      661 ctgtttgctg gatccgctcc attgagtgtg tttactctaa gtacaatttc aacagttatt
      721 tcaatcagac aattgtatca taatgggtgc tcaggtttca tcacagaaag tgggcgcaca
      781 tgaaaactca aatagagcgt atggtggttc taccattaat tacaccacca ttaattatta
      841 tagagattca gctagtaacg cggcttcgaa acaggacttc tctcaagacc cttccaagtt
      901 caccgagccc atcaaggatg tcctgataaa aacagcccca atgctaaact cgccaaacat
      961 agaggcttgc gggtatagcg atagagtact gcaattaaca ctgggaaact ccactataac
     1021 cacacaggag gcggctaatt cagtagtcgc ttatgggcgt tggcctgaat atctgaggga
     1081 cagcgaagcc aatccagtgg accagccgac agaaccagac gtcgctgcat gcaggtttta
     1141 tacgctagac accgtgtctt ggacgaaaga gtcgcgaggg tggtggtgga agttgcctga
     1201 tgcactgagg gacatgggac tctttgggca aaatatgtac taccactacc taggtaggtc
     1261 cgggtacacc gtgcatgtac agtgtaacgc ctccaaattc caccaggggg cactaggggt
     1321 attcgccgta ccagagatgt gtctggccgg ggatagcaac accactacca tgcacaccag
     1381 ctatcaaaat gccaatcctg gcgagaaagg aggcactttc acgggtacgt tcactcctga
     1441 caacaaccag acatcacctg cccgcaggtt ctgcccggtg gattacctcc ttggaaatgg
     1501 cacgttgttg gggaatgcct ttgtgttccc gcaccagata ataaacctac ggaccaacaa
     1561 ctgtgctaca ctggtactcc cttacgtgaa ctccctctcg atagatagta tggtaaagca
     1621 caataattgg ggaattgcaa tattaccatt ggccccatta aattttgcta gtgagtcctc
     1681 cccagagatt ccaatcacct tgaccatagc ccctatgtgc tgtgagttca atggattaag
     1741 aaacatcacc ctgccacgct tacagggcct gccggtcatg aacacccctg gtagcaatca
     1801 atatcttact gcagacaact tccagtcacc gtgtgcgctg cctgaatttg atgtgacccc
     1861 acctattgac atacccggtg aagtaaagaa catgatggaa ttggcagaaa tcgacaccat
     1921 gattcccttt gacttaagtg ccacaaaaaa gaacaccatg gaaatgtata gggttcggtt
     1981 aagtgacaaa ccacatacag acgatcccat actctgcctg tcactctctc cagcttcaga
     2041 tcctaggttg tcacatacta tgcttggaga aatcctaaat tactacacac actgggcagg
     2101 atccctgaag ttcacgtttc tgttctgtgg attcatgatg gcaactggca aactgttggt
     2161 gtcatacgcg cctcctggag ccgacccacc aaagaagcgt aaggaggcga tgttgggaac
     2221 acatgtgatc tgggacatag gactgcagtc ctcatgtact atggtagtgc catggattag
     2281 caacaccacg tatcggcaaa ccatagatga tagtttcacc gaaggcggat acatcagcgt
     2341 cttctaccaa actagaatag tcgtccctct ttcgacaccc agagagatgg acatccttgg
     2401 ttttgtgtca gcgtgtaatg acttcagcgt gcgcttgttg cgagatacca cacatataga
     2461 gcaaaaagcg ctagcacagg ggttaggtca gatgcttgaa agcatgattg acaacacagt
     2521 ccgtgaaacg gtgggggcgg caacatctag agacgctctc ccaaacactg aagccagtgg
     2581 accaacacac tccaaggaaa ttccggcact caccgcagtg gaaactgggg ccacaaatcc
     2641 actagtccct tctgatacag tgcaaaccag acatgttgta caacataggt caaggtcaga
     2701 gtctagcata gagtctttct tcgcgcgggg tgcatgcgtg accattatga ccgtggataa
     2761 cccagcttcc accacgaata aggataagct atttgcagtg tggaagatca cttataaaga
     2821 tactgtccag ttacggagga aattggagtt cttcacctat tctagatttg atatggaact
     2881 tacctttgtg gttactgcaa atttcactga gactaacaat gggcatgcct taaatcaagt
     2941 gtaccaaatt atgtacgtac caccaggcgc tccagtgccc gagaaatggg acgactacac
     3001 atggcaaacc tcatcaaatc catcaatctt ttacacctac ggaacagctc cagcccggat
     3061 ctcggtaccg tatgttggta tttcgaacgc ctattcacac ttttacgacg gtttttccaa
     3121 agtaccactg aaggaccagt cggcagcact aggtgactcc ctttatggtg cagcatctct
     3181 aaatgacttc ggtattttgg ctgttagagt agtcaatgat cacaacccga ccaaggtcac
     3241 ctccaaaatc agagtgtatc taaaacccaa acacatcaga gtctggtgcc cgcgtccacc
     3301 gagggcagtg gcgtactacg gccctggagt ggattacaag gatggtacgc ttacacccct
     3361 ctccaccaag gatctgacca catatggatt cggacaccaa aacaaagcgg tgtacactgc
     3421 aggttacaaa atttgcaact accacttggc cactcaggat gatttgcaaa acgcagtgaa
     3481 cgtcatgtgg agtagagacc tcttagtcac agaatcaaga gcccagggca ccgattcaat
     3541 cgcaaggtgc aattgcaacg caggggtgta ctactgcgag tctagaagga aatactaccc
     3601 agtatccttc gttggcccaa cgttccagta catggaggct aataactatt acccagctag
     3661 gtaccagtcc catatgctca ttggccatgg attcgcatct ccaggggatt gtggtggcat
     3721 actcagatgt caccacgggg tgatagggat cattactgct ggtggcgaag ggttggttgc
     3781 attttcagac attagagact tgtatgccta cgaagaagaa gccatggaac aaggcatcac
     3841 caattacata gagtcacttg gggccgcatt tggaagtgga tttactcagc agattagcga
     3901 caaaataaca gagttgacca atatggtgac cagtaccatc actgaaaagc tacttaagaa
     3961 cttgatcaag atcatatcct cactagttat tataactagg aactatgaag acaccacaac
     4021 agtgctcgct accctggccc ttcttgggtg tgatgcttca ccatggcagt ggcttagaaa
     4081 gaaagcatgc gatgttctgg agatacctta tgtcatcaag caaggtgaca gttggttgaa
     4141 gaagtttact gaagcatgca acgcagctaa gggactggag tgggtgtcaa acaaaatctc
     4201 aaaattcatt gattggctca aggagaaaat tatcccacaa gctagagata agttggaatt
     4261 tgtaacaaaa cttagacaac tagaaatgct ggaaaaccaa atctcaacta tacaccaatc
     4321 atgccctagt caggaacacc aggaaattct attcaataat gtcagatggt tatccatcca
     4381 gtctaagagg tttgcccctc tttacgcagt ggaagccaaa agaatacaga aactagagca
     4441 tactattaac aactacatac agttcaagag caaacaccgt attgaaccag tatgtttgct
     4501 agtacatggc agccccggaa caggtaaatc tgtagcaacc aacctgattg ctagagccat
     4561 agctgaaaga gaaaacacgt ccacgtactc gctacccccg gatccatcac acttcgacgg
     4621 atacaaacaa cagggagtgg tgattatgga cgacctgaat caaaacccag atggtgcgga
     4681 catgaagctg ttctgtcaga tggtatcaac agtggagttt ataccaccca tggcatccct
     4741 ggaggagaaa ggaatcctgt ttacttcaaa ttacgttcta gcatccacaa actcaagcag
     4801 aatttccccc cccactgtgg cacacagtga tgcattagcc aggcgctttg cgttcgacat
     4861 ggacattcag gtcatgaatg agtattctag agatgggaaa ttgaacatgg ccatggctac
     4921 tgaaatgtgt aagaactgtc accaaccagc aaactttaag agatgctgtc ctttagtgtg
     4981 tggtaaggca attcaattaa tggacaaatc ttccagagtt agatacagta ttgaccagat
     5041 cactacaatg attatcaatg agagaaacag aagatccaac attggcaatt gtatggaggc
     5101 tttgtttcaa ggaccactcc agtataaaga cttgaaaatt gacatcaaga cgagtccccc
     5161 tcctgaatgt atcaatgact tgctccaagc agttgactcc caggaggtga gagattactg
     5221 tgagaagaag ggttggatag tcaacatcac cagccaggtt caaacagaaa ggaacatcaa
     5281 cagggcaatg acaattctac aagcggtgac aaccttcgcc gcagtggctg gagttgtcta
     5341 tgtcatgtat aaactgtttg ctggacacca gggagcatac actggtttac caaacaaaaa
     5401 acccaacgtg cccaccattc ggacagcaaa ggtacaagga ccagggttcg attacgcagt
     5461 ggctatggct aaaagaaaca ttgttacagc aactactagc aagggagagt tcactatgtt
     5521 aggagtccac gacaacgtgg ctattttacc aacccacgct tcacctggtg aaagcattgt
     5581 gatcgatggc aaagaagtgg agatcttgga tgccaaagcg ctcgaagatc aagcaggaac
     5641 caatcttgaa atcactataa tcactctaaa gagaaatgaa aagttcagag acattagacc
     5701 acatatacct actcaaatca ctgagacaaa tgatggagtc ttgatcgtga acactagcaa
     5761 gtaccccaat atgtatgttc ctgtcggtgc tgtgactgaa cagggatatc taaatctcgg
     5821 tgggcgccaa actgctcgta ctctaatgta caactttcca accagagcag gacagtgtgg
     5881 tggagtcatc acatgtactg ggaaagtcat cgggatgcat gttggtggga acggttcaca
     5941 cgggtttgca gcggccctga agcgatcata cttcactcag agtcaaggtg aaatccagtg
     6001 gatgagacct tcgaaggaag tgggatatcc aatcataaat gccccgtcca aaaccaagct
     6061 tgaacccagt gctttccact atgtgtttga aggggtgaag gaaccagcag tcctcactaa
     6121 aaacgatccc aggcttaaga cagactttga ggaggcaatt ttctccaagt acgtgggtaa
     6181 caaaattact gaagtggatg agtacatgaa agaggcagta gaccactatg ctggccagct
     6241 catgtcacta gacatcaaca cagaacaaat gtgcttggag gatgccatgt atggcactga
     6301 tggtctagaa gcacttgatt tgtccaccag tgctggctac ccttatgtag caatgggaaa
     6361 gaagaagaga gacatcttga acaaacaaac cagagacact aaggaaatgc aaaaactgct
     6421 cgacacatat ggaatcaacc tcccactggt gacttatgta aaggatgaac ttagatccaa
     6481 aacaaaggtt gagcagggga aatccagatt aattgaagct tctagtttga atgactcagt
     6541 ggcaatgaga atggcttttg ggaacctata tgctgctttt cacaaaaacc caggagtgat
     6601 aacaggttca gcagtggggt gcgatccaga tttgttttgg agcaaaattc cggtattgat
     6661 ggaagagaag ctgtttgctt ttgactacac agggtatgat gcatctctca gccctgcttg
     6721 gttcgaggca ctaaagatgg tgcttgagaa aatcggattc ggagacagag ttgactacat
     6781 cgactaccta aaccactcac accacctgta caagaataaa acatactgtg tcaagggcgg
     6841 tatgccatct ggctgctcag gcacttcaat ttttaactca atgattaaca acttgattat
     6901 caggacactc ttactgaaaa cctacaaggg catagattta gaccacctaa aaatgattgc
     6961 ctatggtgat gatgtaattg cttcctaccc ccatgaagtt gacgctagtc tcctagccca
     7021 atcaggaaaa gactatggac taactatgac tccagctgac aaatcagcta catttgaaac
     7081 agtcacatgg gagaatgtaa cattcttgaa gagattcttc agggcagacg agaaataccc
     7141 atttcttatt catccagtaa tgccaatgaa ggaaattcat gaatcaatta gatggactaa
     7201 agatcctagg aacactcagg atcacgttcg ctctctgtgc cttttagctt ggcacaatgg
     7261 cgaagaagaa tataacaaat tcctagctaa aatcaggagt gtgccaattg gaagagcttt
     7321 attgctccca gagtactcaa cattgtaccg ccgttggctt gactcatttt agtaacccta
     7381 cctcagtcga attggattgg gtcatactgt tgtaggggta aatttttctt taattcggag
//

