Entry information
Entry name | DNP_DENAN
Primary accession | P28374
integrated into UniProtKB/Swiss-Prot | 01 December 1992
sequence version 1 | 01 December 1992
entry version 46 | 19 January 2010
Name and origin of the protein
Protein name | Natriuretic peptide
DNP
From | Dendroaspis angusticeps (Eastern green mamba) (Taxon ID: 8618)
Taxonomy | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Scleroglossa; Serpentes; Colubroidea; Elapidae; Elapinae; Dendroaspis
Keywords | Direct protein sequencing; Disulfide bond; Ionic channel inhibitor; Potassium channel inhibitor; Secreted; Toxin; Vasoactive
References
1 | Schweitz H., Vigne P., Moinier D., Frelin C., Lazdunski M.; "A new member of the natriuretic peptide family is present in the venom of the green mamba (Dendroaspis angusticeps)." J. Biol. Chem. 267:13928-13932(1992)
MEDLINE | 92332489
PubMed | 1352773
Reference Position | protein sequence, function, subcellular location, and tissue specificity.
Reference Comment | tissue=venom
2 | Lisy O., Jougasaki M., Heublein D.M., Schirger J.A., Chen H.H., Wennberg P.W., Burnett J.C.; "Renal actions of synthetic dendroaspis natriuretic peptide." Kidney Int. 56:502-508(1999)
PubMed | 10432389
DOI | 10.1046/j.1523-1755.1999.00573.x
Reference Position | function.
3 | Collins E., Bracamonte M.P., Burnett J.C. Jr., Miller V.M.; "Mechanism of relaxations to dendroaspis natriuretic peptide in canine coronary arteries." J. Cardiovasc. Pharmacol. 35:614-618(2000)
PubMed | 10774793
DOI | 10.1097/00005344-200004000-00015
Reference Position | function.
4 | Lisy O., Lainchbury J.G., Leskinen H., Burnett J.C. Jr.; "Therapeutic actions of a new synthetic vasoactive and natriuretic peptide, dendroaspis natriuretic peptide, in experimental severe congestive heart failure." Hypertension 37:1089-1094(2001)
PubMed | 11304508
Reference Position | function.
5 | Chai O.H., Kim E.K., Lee Y.H., Kim J.G., Baik B.J., Lee M.S., Han E.H., Kim H.T., Song C.H.; "Histamine release induced by dendroaspis natriuretic peptide from rat mast cells." Peptides 22:1421-1426(2001)
PubMed | 11514023
DOI | 10.1016/S0196-9781(01)00483-1
Reference Position | function.
6 | Best P.J., Burnett J.C., Wilson S.H., Holmes D.R. Jr., Lerman A.; "Dendroaspis natriuretic peptide relaxes isolated human arteries and veins." Cardiovasc. Res. 55:375-384(2002)
PubMed | 12123777
DOI | 10.1016/S0008-6363(02)00402-9
Reference Position | function.
7 | Chen H.H., Lainchbury J.G., Burnett J.C. Jr.; "Natriuretic peptide receptors and neutral endopeptidase in mediating the renal actions of a new therapeutic synthetic natriuretic peptide dendroaspis natriuretic peptide." J. Am. Coll. Cardiol. 40:1186-1191(2002)
PubMed | 12354448
DOI | 10.1016/S0735-1097(02)02127-7
Reference Position | degradation of dnp.
8 | Singh G., Kuc R.E., Maguire J.J., Fidock M., Davenport A.P.; "Novel snake venom ligand dendroaspis natriuretic peptide is selective for natriuretic peptide receptor-A in human heart: downregulation of natriuretic peptide receptor-A in heart failure." Circ. Res. 99:183-190(2006)
PubMed | 16778132
DOI | 10.1161/01.RES.0000232322.06633.d3
Reference Position | function, and npr1 binding.
9 | Johns D.G., Ao Z., Heidrich B.J., Hunsberger G.E., Graham T., Payne L., Elshourbagy N., Lu Q., Aiyar N., Douglas S.A.; "Dendroaspis natriuretic peptide binds to the natriuretic peptide clearance receptor." Biochem. Biophys. Res. Commun. 358:145-149(2007)
PubMed | 17475216
DOI | 10.1016/j.bbrc.2007.04.079
Reference Position | function, and npr3 binding.
10 | Guo H.-S., Yang Y.-Z., Zou Y., Xu J., Cai Z.-X., Qi Q.-H.; "Effects of dendroaspis natriuretic peptide on calcium-activated potassium current and its mechanism." J. Physiol. Sci. 58:1-6(2008)
PubMed | 18096107
DOI | 10.2170/physiolsci.RP010507
Reference Position | function on potassium channel.
Comments
function | Exhibits vasodilator, natriuretic and diuretic properties in animal models and human tissues. Acts by stimulating cGMP via the natriuretic peptide receptor A (NPR1). Is a poor agonist of the atrial natriuretic peptide receptor B (NPR2). Is not degradated by neutral endopeptidase (NEP / MME). Binds to atrial natriuretic peptide clearance receptor (NPR3 / NPR-C), which may be responsible of the removal of DNP from the circulation. Increases calcium uptake and induces histamine release from rat peritoneal mast cells. Increases calcium- activated potassium current in gastric antral circular smooth muscle cells by increasing cGMP production and activating inositol trisphosphate receptors (IP3Rs).
subcellular location | Secreted.
tissue specificity | Expressed by the venom gland.
similarity | Belongs to the natriuretic peptide family.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
PIR | A42974; A42974.
GO | ; C:extracellular region; IEA:UniProtKB-SubCell.
; F:hormone activity; IEA:InterPro.
; F:potassium channel inhibitor activity; IEA:UniProtKB-KW.
; P:pathogenesis; IEA:UniProtKB-KW.
; P:regulation of blood vessel size; IEA:UniProtKB-KW.
InterPro | IPR000663; Natr_peptide.
Pfam | PF00212; ANP; 1.
PROSITE | PS00263; NATRIURETIC_PEPTIDE; 1.
Features
Key | From | To | Length | Description
--- | --- | --- | --- | ---
peptide | 1 | 38 | 38 | Natriuretic peptide. /FTId=PRO_0000045068.
disulfid | 7 | 23 | 17 | By similarity.
Sequence information
Length: 38 aa, molecular weight 4193 Da, CRC64 checksum BCAD19AB95B52258
    EVKYDPCFGH KIDRINHVSN LGCPSLRDPR PNAPSTSA